QuoData Publications and Papers on Statistics for Analytical Quality Assurance

Essential terminology and considerations for validation of non-target methods

Nichani, Kapil; Uhlig, Steffen; Stoyke, Manfred; Kemmlein, Sabine; Ulberth, Franz; Haase, Ilka; Döring, Maik; G Walch; Stephan; Gowik, Petra (2023)

Published in:

Food Chemistry; https://www.sciencedirect.com/science/article/pii/S2590157522003364?via%3Dihub

Development of Non-Targeted Mass Spectrometry Method for Distinguishing Spelt and Wheat

Nichani, Kapil; Uhlig, Steffen; Colson, Bertrand; Hettwer, Karina; Simon, Kirsten; Bönick, Josephine; Uhlig, Carsten; Kemmlein, Sabine; Stoyke, Manfred; Gowik, Petra; Husschek, Gerd; M.Rawel, Harshadrai (2023)

Published in:

Food; https://www.mdpi.com/2304-8158/12/1/141

Measurement Uncertainty Interval In Case of a Known Relationship between Precision and Mean

Uhlig, Steffen; Colson, Bertrand; Gowik, Petra (2022)

Published in:

Preprints; https://www.preprints.org/manuscript/202208.0179/v1

Digital Droplet-PCR for Quantification of Viable Campylobacter jejuni and Campylobacter coli in Chicken Meat Rinses

Digital Droplet-PCR for Quantification of Viable Campylobacter jejuni and Campylobacter coli in Chicken Meat Rinses

Published in:

Applied Sciences; https://www.mdpi.com/2076-3417/12/11/5315

Interlaboratory Validation of a DNA Metabarcoding Assay for Mammalian and Poultry Species to Detect Food Adulteration

Dobrovolny, Stefanie; Uhlig, Steffen; Frost, Kirstin; Schlierf, Anja; Nichani, Kapil; Simon, Kirstin; Cichna-Markl, Margit; Hochegger, Rupert (2022)

Published in:

In: Foods; https://www.mdpi.com/2304-8158/11/8/1108/htm

Interlaboratory Validation of a DNA Metabarcoding Assay for Mammalian and Poultry Species to Detect Food Adulteration

Uhlig, Steffen; Weidner, Christopher; Colson, Bertrand (2022)

Published in:

Preprints; https://www.preprints.org/manuscript/202204.0104/v1

Statistical Modelling and Experimental Design for the Validation of Droplet Digital PCR Methods

Deng, Kaiping; Uhlig, Steffen; Goodman, Laura B.; Ip, Hon S.; Killian, Mary Lea Killian; Nemser, Sarah M.; Ulaszek, Jodie; Kiener, Shannon; Kmet, Matthew;  Frost, Kirstin; Hettwer, Karina; Colson, Bertrand; Nichani, Kapil; Schlierf, Anja; Tkachenko, Andriy; Mlalazi-Oyinloye, Mothomang; Scott, Andrew; Reddy,Ravinder; Tyson, Gregory H (2022).

Published in:

Medrxiv; https://www.medrxiv.org/content/10.1101/2022.04.08.22273621v1

Interlaboratory comparison of SARS-CoV2 molecular detection assays in use by U.S.veterinary diagnostic laboratories 

Deng, Kaiping; Uhlig, Steffen; Ip, Hon S.; Killian, Mary Lea; Goodman, Laura B.; Nemser, Sarah; Ulaszek, Jodie; Pickens, Shannon; Newkirk, Robert; Kmet, Matthew; Frost, Kirstin; Hettwer, Karina; Colson, Bertrand; Nichani, Kapil; Schlierf, Anja; Tkachenko, Andriy; Reddy, Ravinder; Reimschuessel, Renate (2021)

Published in:

Journal of Veterenary Diagnostic Investigation; https://doi.org/10.1177%2F10406387211029913

PReal-Time PCR Assay for the Detection and Quantification of Roe Deer to Detect Food Adaulteration - Interlaboratory Validation Onvolving Laboratories in Austria, Germany and Switzerland

Druml, Barbara; Uhlig, Steffen; Simon, Kirsten; Frost, Kirstin; Hettwer, Karina; Cichna-Markl, Margit; Hochegger, Rupert (2021)

Published in:

Foods; https://www.mdpi.com/2304-8158/10/11/2645

PReal-Time PCR Assay for the Detection and Quantification of Roe Deer to Detect Food Adaulteration - Interlaboratory Validation Onvolving Laboratories in Austria, Germany and Switzerland

Dreyer, Annekatrin; Kube, Christine; Frost, Kirstin (2021)

Published in:

Umweltbundesamtes; www.umweltbundesamt.de/publikationen/polychlorierte-dibenzodioxine-furane-pcddf-in-der

CEQAT-DGHS interlaboratory tests for chemical safety: Validation of laboratory test methods by determining the measurement uncertainty and probability of incorrect classification including so-called “Shark profiles”

Lüth, Peter; Uhlig, Steffen; Frost, Kirstin; Malow, Marcus; Micheal-Schulz, Heike; Schmidt, Martin; Zakel, Sabine (2021)

Published in:

Elsevier; https://doi.org/10.1016/j.jlp.2021.104532

Survey of gunshot residue prevalence on the hands of individuals from various population groups in and outside Europe

Stamouli, Amalia; Niewöhner, Ludwig; Larsson, Magnus; Colson, Bertrand; Uhlig, Steffen; Fojtasek, Lubor; Machado, Fatima; Gunaratnam, Lawrence (2021)

Published in:

Forensic Chemistry; https://doi.org/10.1016/j.forc.2021.100308

Validation of binary non-targeted approaches: mathematical frameworks and experimental designs

Uhlig, Steffen; Nichani, Kapil; Stoyke, Manfred; Gowik, Petra (2021)

Published in:

bioRxiv; https://www.biorxiv.org/content/10.1101/2021.01.19.427235v1.full.pdf​

Al-based identification of grain cultivars via non-target mass spectrometry

Nichani, Kapil; Uhlig, Steffen.; Colson, Bertrand.; Hettwer, Karina.; Simon, Kirsten.; Bönick, Josephine; Uhlig, Carsten.; Rawel, Harshadrai M.; Stoyke, Manfred.; Gowik, Petra.; Huschek, Gerd (2020)

Published in:

medRxiv https://doi.org/10.1101/2020.05.07.08206

Modeling projections for COVID-19 pandemic by combining epidemiological, statistical, and neural network approaches

Osterwalder, Uli; Uhlig, Steffen; Colson, Bertrand; Vollhardt, Jürgen (2020)

Published in:

Cosmetics & Toiletries 135 (4), p. 40-52

Modeling projections for COVID-19 pandemic by combining epidemiological, statistical, and neural network approaches

Uhlig, Steffen; Nichani, Kapil; Uhlig, Carsten; Simon, Kirsten (2020)

Published in: 

medRxiv https://www.medrxiv.org/content/10.1101/2020.04.17.20059535v1.full.pdf+html

https://doi.org/10.1101/2020.04.17.20059535 

CEQAT-DGHS interlaboratory tests for chemical safety: Validation of laboratory test methods by determining the measurement uncertainty and probability of incorrect classification including so-called "Shark profiles"

Uhlig, Steffen; Hettwer, Karina; Simon, Kirsten; Terytze, Konstantin (2020)

Published in: 

altlasten spektrum, S. 141-144; https://www.altlastendigital.de/ce/ermittlung-der-analytischen-unsicherheit-fuer-chemische-bodenuntersuchungen/_sid/OXPT-398229-kufF/detail.html​

CEQAT-DGHS interlaboratory tests for chemical safety: Validation of laboratory test methods by determining the measurement uncertainty and probability of incorrect classification including so-called "Shark profiles"

Lüth, Peter; Uhlig, Steffen; Frost, Kirstin; Malow, Marcus; Michael-Schulz, Heike; Schmidt, Martin; Zakel, Sabine (2020)

Published in:

Proceedings of the 13th International Symposium on Hazards, Prevention and Mitigation of Industrial Explosions (ISHPMIE 2020), S. 50-61; https://opus4.kobv.de/opus4-bam/frontdoor/index/index/docId/51537​

Eine neue Handlungsanleitung für den Vollzug des Bodenschutzes

Steffen Uhlig, Karina Hettwer, Kirstin Frost, Henning Baldauf, Kirsten Simon, Frank Küchler, Achim Willand, Moriz Felder, Konstantin Terytze (2019)

Published in:

altlasten spektrum, p. 165-175

Development and In-House Validation of an LC-MS and LC-MS/MS Assay for the Determination of Food Fraud for Different Fish Species

Lasch, Philipp; Uhlig, Steffen; Uhlig, Carsten; Wilhelm, Christian; Bergmann, Nicola; Wittke, Stefan (2019)

Published in: 

Journal of AOAC International 102, p. 1-9

Assessing the equivalence of Vibrio parahaemolyticus MPN and PCR Quantification Methods in Oyster Samples: A Seven-Year Study

Lindemann, Samantha; Colson, Bertrand; Newkirk, Robert; Uhlig, Steffen; REDDY, RAVINDER (2019)

Published in:

Food Microbiology 84 (2019) 103163

Assessing the equivalence of Vibrio parahaemolyticus MPN and PCR Quantification Methods in Oyster Samples: A Seven-Year Study

Stoyke, Manfred; Becker, René; Brockmeyer, Jens; Jira, Wolfgang; Popping, Bert; Uhlig, Steffen; Wittke, Stefan (2019)

Published in: 

Journal of AOAC International 102, p. 1-6

Valid machine learning algorithms for multiparameter methods

Uhlig, Steffen; Colson, Bertrand; Hettwer, Karina; Simon, Kirsten; Uhlig, Carsten; Wittke, Stefan; Stoyke, Manfred; Gowik, Petra (2019)

Published in:

Accreditation and Quality Assurance 575 (1), p. 265

A mathematical approach for the analysis of data obtained from the monitoring of biocides leached from treated materials exposed to outdoor conditions

Uhlig, Steffen; Colson, Bertrand; Schoknecht, Ute (2019)

Published in:

Chemosphere 228, p. 271-277

CEQAT-DGHS Interlaboratory Test Programme for Chemical Safety - Need of Test Methods Validation

CEQAT-DGHS Interlaboratory Test Programme for Chemical Safety - Need of Test Methods Validation

Published in:

Chemical Engineering Transactions 77

The case of low participant numbers: Taking laboratory uncertainties into account in the Hampel estimator  

Steffen Uhlig, Bertrand Colson (2019)

Published in:

Proceedings of the 7th International Proficiency Testing Conference, p. 16-23.

Taking laboratory uncertainties into account in the Hampel estimator

Steffen Uhlig, Bertrand Colson, Petra Gowik (2018)

Published in:

Accreditation and Quality Assurance

https://link.springer.com/article/10.1007/s00769-018-1332-x

Das erste Treffen der § 64 LFGB Arbeitsgruppe „Massenspektrometrische Proteinanalytik“

Becker, René; Wittke, Stefan; Brockmeyer, Jens; Schwägele, Fredi; Jira, Wolfgang; Uhlig, Steffen; Pöpping, Bert; Szabo, Kathrin; Stoyke, Manfred (2018)

Published in:

Journal of Consumer Protection and Food Safety 101 (1), S. 96

Effect-based trigger values for in vitro and in vivo bioassays performed on surface water extracts supporting the environmental quality standards (EQS) of the European Water Framework Directive

Escher, Beate I.; Aїt-Aїssa, Selim; Behnisch, Peter A.; Brack, Werner; Brion, François; Brouwer, Abraham; Buchinger, Sebastian; Crawford, Sarah E.; Du Pasquier, David; Hamers, Timo; Hettwer, Karina; Hilscherová, Klára; Hollert, Henner; Kase, Robert; Kienle, Cornelia; Tindall, Andrew J.; Tuerk, Jochen; van der Oost, Ron; Vermeirssen, Etienne; Neale, Peta A. (2018)

Published in:

Science of The Total Environment 628-629, S. 748–765

Efficient estimation of interlaboratory and in-house reproducibility standard deviation in factorial validation studies

Uhlig, Steffen; Gowik, Petra (2018)

Published in:

J Consum Prot Food Saf 123 (1), S. 173

Efficient estimation of the limit of detection and the relative limit of detection along with their reproducibility in the validation of qualitative microbiological methods by means of generalized linear mixed models

Uhlig, Steffen; Gowik, Petra (2018)

Published in:

J Consum Prot Food Saf 13 (1), S. 79–87

https://link.springer.com/article/10.1007/s00003-017-1130-0

Validation of Arxula Yeast Estrogen Screen assay for detection of estrogenic activity in water samples: Results of an international interlaboratory study

Karina Hettwer, Martin Jähne, Kirstin Frost, Martin Giersberg, Gotthard Kunze, Michael Trimborn, Martin Reif, Jochen Türk, Linda Gehrmann, Freddy Dardenne, Femke De Croock, Marion Abraham, Anne Schoop, Joanna J.Waniek, Thomas Bucher, Eszter Simon, Etienne Vermeirssen, AnettWerner, Karin Hellauer, UrsulaWallentits, Jörg E. Drewes, Detlef Dietzmann, Edwin Routledge, Nicola Beresford, Tamara Zietek, Margot Siebler, Anne Simon, Helena Bielak, Henner Hollert, Yvonne Müller, Maike Harff, Sabrina Schiwy, Kirsten Simon, Steffen Uhlig (2018)

Published in:

Science of The Total Environment 621, S. 612–625

Improved sensitivity for detection of breast cancer by combination of miR-34a and tumor markers CA 15-3 or CEA

Zaleski, Martin; Kobilay, Makbule; Schroeder, Lars; Debald, Manuel; Semaan, Alexander; Hettwer, Karina; Uhlig, Steffen; Kuhn, Walther; Hartmann, Gunther; Holdenrieder, Stefan (2018)

Published in:

Oncotarget 9 (32), S. 22523–22536

Evaluation of the interlaboratory test 2015 – 2016 on the method UN Test L.2 “Sustained combustibility test” / EN ISO 9038:2013 “Determination of sustained combustibility of liquids"

Brandes, Elisabeth; Colson, Bertrand; Frost, Kirstin; Lüth, Peter; Simon, Kirsten; Stolz, T.; Uhlig, Steffen (2017)

Published in:

Final Report. Hg. v. BAM Bundesanstalt für Materialforschung und -prüfung. Berlin

Separation and identification of hormone-active compounds using a combination of chromatographic separation and yeast-based reporter assay.

Chamas, Alexandre; Pham, Ha Thi Minh; Jähne, Martin; Hettwer, Karina; Gehrmann, Linda; Tuerk, Jochen; Uhlig, Steffen; Simon, Kirsten; Baronian, Kim; Kunze, Gotthard (2017)

Published in:

Science of The Total Environment 605-606, S. 507–513.

Separation and identification of hormone-active compounds using a combination of chromatographic separation and yeast-based reporter assay

Chamas, Alexandre; Pham, Ha Thi Minh; Jähne, Martin; Hettwer, Karina; Uhlig, Steffen; Simon, Kirsten; Einspanier, Almuth; Baronian, Kim; Kunze, Gotthard (2017)

Published in:

Biotechnol. Bioeng. 114 (7), S. 1539–1549

Carcinoembryonic antigen and cytokeratin-19 fragments for assessment of therapy response in non-small cell lung cancer: a systematic review and meta-analysis

Holdenrieder, Stefan; Wehnl, Birgit; Hettwer, Karina; Simon, Kirsten; Uhlig, Steffen; Dayyani, Farshid (2017)

Published in:

Br J Cancer 16, S. 242

Diagnostic relevance of a novel multiplex immunoassay panel in breast cancer

Hermann, Natalie; Dressen, Katja; Schroeder, Lars; Debald, Manuel; Schildberg, Frank A.; Walgenbach-Bruenagel, Gisela; Hettwer, Karina; Uhlig, Steffen; (2017)

Published in:

Tumor Biology 39 (6), S. 1–11

Diagnostic relevance of a novel multiplex immunoassay panel in breast cancer

Dressen, Katja; Hermann, Natalie; Manekeller, Steffen; Walgenbach-Bruenagel, Gisela; Schildberg, Frank A.; Hettwer, Karina; Uhlig, Steffen; Kalff, Jörg C.; Hartmann, Gunther; Holdenrieder, Stefan (2017)

Published in:

Anticancer Research 37 (5), S. 2477–2486

Emissions of material preservatives into the environment – realistic estimation of environmental risks through the improved characterisation of the leaching of biocides from treated materials used outdoors

Schoknecht, Ute; Maties, Helena; Wegner, Robby; Uhlig, Steffen; Baldauf, Henning; Colson, Bertrand (2016)

Published in:

https://www.umweltbundesamt.de/publikationen/emissions-of-material-preservatives-into-the

Guidelines for the validation of qualitative real-time PCR methods by means of a collaborative study

Grohmann, Lutz; Hermann Broll; Dagand, Emilie; Zur, KatrinUhlig; Uhlig, Steffen et al.  (2016)

Measurement uncertainty in the case of large and heterogeneous variances: A new approach for the calculation of asymmetric uncertainty intervals.

Uhlig, Steffen; Gowik, Petra (in Bearbeitung)

Published in:

Accreditation and Quality Assurance.

Guidelines for the single-laboratory validation of qualitative real-time PCR methods 

Grohmann, Lutz; Hermann Broll; Dagand, Emilie; Zur, KatrinUhlig; Uhlig, Steffen et al.  (2016)

Determination of Gluten in Processed and Nonprocessed Corn Products by Qualitative R5 Immunochromatographic Dipstick: Collaborative Study, First Action 2015.16

Pham, Ha Thi Minh; Chamas, Alexandre; Nieter, Annabel; Giersberg, Martin; Rutten, Twan; Gehrmann, Linda; Hettwer, Karina; Tuerk, Jochen; Uhlig, Steffen; Simon, Kirsten; Baronian, Kim; Kunze, Gotthard (2016)

Published in:

http://dx.doi.org/10.1016/j.snb.2015.09.132

Validation of a qualitative R5 dip-stick for gluten detection with a new mathematical-statistical approach

Scherf, K.A; Uhlig, S.; Simon, K.; Frost, K.; Koehler, P.; Weiss, T.; Lacorn, M. (2016)

Published in:

http://dx.doi.org/10.3920/QAS2015.0818

Matrix-Specific Method Validation of an Automated Most-Probable-Number System for Use in Measuring Bacteriological Quality of Grade "A" Milk Products

Lindemann, S.; M. Kmet; R. REDDY; S. Uhlig (2016)

Published in:

Journal of Food Protection 79 (11), S. 1911–1918

https://doi.org/10.4315/0362-028X.JFP-16-141 

PROLab software for data evaluation of interlaboratory studies

Bebić, Jelena M.; Gažević, Luka S.; Bläul, Christian (2016)

Published in:

International Journal ’’Advanced Quality’’ 44 (3), S. 8–13

http://journal.jusk.rs/index.php/ijaq/article/view/19

Determination of Gluten in Processed and Nonprocessed Corn Products by Qualitative R5 Immunochromatographic Dipstick: Collaborative Study, First Action 2015.16.

Lacorn, Markus; Scherf, Katharina; Uhlig, Steffen; Weiss, Thomas (2016)

Published in:

http://dx.doi.org/10.5740/jaoacint.16-0017

Purification and immunodetection of the complete recombinant HER-2[neu] receptor produced in yeast

Chamas, Alexandre; Giersberg, Martin; Friedrich, Katrin; Sonntag, Frank; Kunze, Dietmar; Uhlig, Steffen et al. (2015)

Published in:

Protein Expression and Purification (105), p. 61–70.

http://dx.doi.org/10.1016/j.pep.2014.10.004

Validation of qualitative PCR methods on the basis of mathematical–statistical modelling of the probability of detection

Uhlig, Steffen; Frost, Kirstin; Colson, Bertrand; Simon, Kirsten; Mäde, Dietrich; Reiting, Ralf et al. (2015)

Published in:

Accreditation and Quality Assurance 20 (2), p. 75–83

http://dx.doi.org/10.1007/s00769-015-1112-9

Qualitative PT data analysis with easy-to-interpret scores

Uhlig, Steffen; Bläul, Christian; Frost, Kirstin; Sgorzaly, Susann; Colson, Bertrand; Simon, Kirsten (2015)

Published in:

Accreditation and Quality Assurance 20 (5), p. 347–353

http://dx.doi.org/10.1007/s00769-015-1174-8

Mathematical-statistical procedure for determining the concentration-dependent probability of detection of qualitative chemical methods on the basis of interlaboratory study data.

Uhlig, Simon; Simon, Kirsten; Frost, Kirstin (2015)

Published in:

Hg. v.  QuoData GmbH

availabe upon request

Messunsicherheit für Verfahren zum Vollzug und zur Weiterentwicklung der Bundes-Bodenschutz- und Altlastenverordnung

Uhlig, Steffen; Baldauf, Henning (2015)

Published in:

Hg. v. Umweltbundesamt. Fachbereich für Bodenuntersuchungen

https://www.umweltbundesamt.de/sites/default/files/medien/359/dokumente/messunsicherheit-bbodschv.pdf

Ableitung der konzentrationsabhängigen Messunsicherheit bei Bodenelutionsverfahren

Uhlig, Steffen; Baldauf, Henning (2015)

Published in:

Umweltbundesamt; Fraunhofer IME

https://www.umweltbundesamt.de/sites/default/files/medien/359/dokumente/konzentrationsabhaengigen_messunsicherheit_bei_bodenelutionsverfahren.pdf

Robust estimation of between and within laboratory standard deviation with measurement results below the detection limit

Uhlig, Steffen (2015)

Published in:

In: Journal für Verbraucherschutz und Lebensmittelsicherheit (10), p. 385–391

http://dx.doi.org/10.1007/s00003-015-0967-3

The determination of pharmaceuticals in wastewater using a recombinant Arxula adeninivorans whole cell biosensor

Pham, Ha Thi Minh; Giersberg, Martin; Gehrmann, Linda; Hettwer, Karina; Tuerk, Jochen; Uhlig, Steffen et al. (2015)

Published in:

Sensors and Actuators B: Chemical (211), p. 439–448

http://dx.doi.org/10.1016/j.snb.2015.01.107

Novel Serum Nucleosomics Biomarkers for the Detection of Colorectal Cancer

Holdenrieder, Stefan; Dharuman, Yoganiranjana; Standop, Jens; Trimpop, Nicolai; Herzog, Marielle; Hettwer, Karina et al. (2014)

Published in:

Anticancer Research (34), p. 2357–2362

http://ar.iiarjournals.org/content/34/5/2357.full

Apoptosis-related biomarkers in patients with gynecological cancer

Hermann, Natalie; Dressen, Katja; Schroeder, Lars; Debald, Manuel; Keyver-Paik, Mignon; Abramian, Alina et al. (2015)

Published in:

CP 53 (12), p. 1059–1061

http://dx.doi.org/10.5414/CPCES14EA10

Kinetic Analyses of Data from a Human Serum Albumin Assay Using the liSPR System

Henseleit, Anja; Pohl, Carolin; Kaltenbach, Hans-Michael; Hettwer, Karina; Simon, Kirsten; Uhlig, Steffen et al. (2015)

Published in:

Biosensors 5 (1), p. 27–36.

http://dx.doi.org/10.3390/bios5010027

Zielgerichtete Erhebung experimenteller Daten als Grundlage zur Ableitung der konzentrationsabhängigen Messunsicherheit bei Bodenelutionsverfahren. Abschlussbericht zum F+E Vorhaben

Hennecke, Dieter; Uhlig, Steffen; Baldauf, Henning (2015)

Published in:

Hg. v. Umweltbundesamt. Fraunhofer IME; Deutsches Institut für Normung.

https://www.umweltbundesamt.de/sites/default/files/medien/359/dokumente/zielgerichtete_erhebung_experimenteller_daten_als_grundlagemessunsicherheit_bei_bodenelutionsverfahren.pdf

Collaborative trial validation of cry1Ab/Ac and Pubi-cry TaqMan-based real-time PCR assays for detection of DNA derived from genetically modified Bt plant products.

Grohmann, Lutz; Reiting, Ralf; Mäde, Dietrich; Uhlig, Steffen; Simon, Kirsten; Frost, Kirstin et al. (2015)

Published in:

Accreditation and Quality Assurance 20 (2), p. 85–96.

http://dx.doi.org/10.1007/s00769-015-1108-5

Apoptosis-related biomarkers in patients with gastrointestinal cancer.

Dressen, Katja; Hermann, Natalie; Manekeller, Steffen; Bruenagel, Gisela Walgenbach; Schildberg, Frank A.; Hettwer, Karina et al. (2015)

Published in:

CP 53 (12), p. 1062–1064.

http://dx.doi.org/10.5414/CPCES14EA11

Development of a recombinant Arxula adeninivorans cell bioassay for the detection of molecules with progesterone activity in wastewater

Chamas, Alexandre; Nieter, Annabel; Pham, Ha Thi Minh; Giersberg, Martin; Hettwer, Karina; Uhlig, Steffen et al. (2015)

Published in:

Analytical and Bioanalytical Chemistry 407 (26), p. 8109–8120.

http://dx.doi.org/10.1007/s00216-015-8985-7

Development and assessment of a novel Arxula adeninivorans androgen screen (A-YAS) assay and its application in analysis of cattle urine.

Gerlach, Torsten; Knaust, Jacqueline; Kaiser, Christian; Körner, Martina; Hettwer, Karina; Uhlig, Steffen et al. (2014)

Published in:

Science of The Total Environment (490), p. 1073–1081.

http://dx.doi.org/10.1016/j.scitotenv.2014.05.100

Method Validation and Proficiency Testing for Determination of Total Arsenic in Apple Juice by Inductively Coupled Plasma/Mass Spectrometry.

Chen, Yang; Reddy, Ravinder M.; McLaughlin, Michael A.; Al-Taher, Fadwa; Yettella, Ramesh R.; Uhlig, Steffen; Bläul, Christian (2014)

Published in:

Journal of AOAC International 97 (4), p. 1143–1150.

http://dx.doi.org/10.5740/jaoacint.13-207

The Untold History of Algorithm A.

Colson, Bertrand (2014)

Published in:

Hg. v. QuoData GmbH.

https://quodata.de/en/company/algorithm-a.html

How reliable are your results? Advancing Laboratory Quality Culture through Effective Proficiency Testing and Data Analysis.

Uhlig, Steffen (2014)

Published in:

eFOOD-Lab international 14 (3), p. 12–15

A new generation of Arxula based assays to detect environmental pollutans.

Giersberg, Martin; Rutten, Twan; Floß, Doreen; Uhlig, Steffen; Kunze, Gotthard (2013)

Published in:

Yeast 30 (S1), p. 217–235.

available upon request

Statistisch abgesicherte Interpretation von SPR-Biochipsignalen via SPRING. Statistically Verified SPR Data Analysis via SPRING

Krügener, Sven; Hettwer, Karina; Simon, Kirsten; Uhlig, Steffen (2013)

Published in:

tm - Technisches Messen 80 (9), p. 299–304.

http://dx.doi.org/10.1524/teme.2013.0013

Monitoring of endocrine disruptors in waste water treatment using Arxula adeninivorans based biosensors.

Krügener, Sven; Hettwer, Karina; Jähne, Martin; Uhlig, Steffen; Kunze, Gotthard (2013)

Published in:

26th International Conference on Yeast Genetics and Molecular Biology. 26th International Conference on Yeast Genetics and Molecular Biology. Frankfurt am Main, 29. August - 3. September. Goethe Universität Frankfurt am Main, p. 30(S1), 214.

available upon request

Application of modified Arxula adeninivorans yeast cells in an online biosensor for the detection of estrogenic compounds in wastewater samples.

Pham, Ha Thi Minh; Kunath, Kirstin; Gehrmann, Linda; Giersberg, Martin; Tuerk, Jochen; Uhlig, Steffen et al. (2013)

Published in:

Sensors and Actuators B: Chemical 185, p. 628–637.

http://dx.doi.org/10.1016/j.snb.2013.05.065

Reliability of Precision Data Obtained from Interlaboratory Studies.

Uhlig, Steffen; Eichler, Stefanie; Gowik, Petra (2013)

Published in:

Journal of AOAC International 96 (2), p. 466–470.

http://dx.doi.org/10.5740/jaoacint.11-365

A new profile likelihood confidence interval for the mean probability of detection in collaborative studies of binary test methods.

Uhlig, Steffen; Krügener, Sven; Gowik, Petra (2013)

Published in:

Accreditation and Quality Assurance 18 (5), p. 367–372.

http://dx.doi.org/10.1007/s00769-013-0993-8

Analytische Qualitätssicherung. Ringversuche und QS-Messungen aus einem anderen Blickwinkel.

Bläul, Christian; Uhlig, Steffen; Hettwer, Karina; Simon, Kirsten (2012)

Published in:

Deutsche Lebensmittelrundschau 108 (10), p. 541–545

EstraMonitor – A monitor for amperometric detection of estrogenic activity with Arxula adeninivorans yeast cells as the biocomponent.

Pham, Ha Thi Minh; Giersberg, Martin; Uhlig, Steffen; Hanke, Gerold; Simon, Kirsten; Kunath, Kirstin et al. (2012)

Published in:

Sensors and Actuators B: Chemical 161 (1), p. 137–145.

http://dx.doi.org/10.1016/j.snb.2011.09.085

Software for the evaluation of interlaboratory studies for CRM. Statistical assessment and uncertainty quantification.

Bläul, Christian (2012)

Published in:

Mineral Resources - Reference Material. Bundesanstalt für Geowissenschaften und Rohstoffe; Central Geological Laboratory. Ulan Bator, 2012

Evaluation of the 3rd Round Robin on Solid Oxidizer Test (UN O.1) with Calcium peroxide, Sodium nitrate, Sodium perborate monohydrate. Final Report, 2009-2011.

Antoni, Sabine; Clemens, Jörg; Kunath, Kirstin; Rabe, Jürgen; Simon, Kirsten; Uhlig, Steffen; Wehrstedt, Klaus-Dieter (2011)

Published in:

Hg. v. BAM Bundesanstalt für Materialforschung und -prüfung. Berlin.

http://www.bam.de/de/service/publikationen/publikationen_medien/fg22_round_robin_solid_oxidizer_test.pdf

Results of a European interlaboratory method validation study for the quantitative determination of lipophilic marine biotoxins in raw and cooked shellfish based on high-performance liquid chromatography–tandem mass spectrometry. Part I: collaborative study.

These, Anja; Klemm, Christine; Nausch, Ingo; Uhlig, Steffen (2011)

Published in:

Analytical and Bioanalytical Chemistry 399 (3), p. 1245–1256.

http://dx.doi.org/10.1007/s00216-010-4383-3

Are the results of customary methods for analyzing dioxin and dioxin-like compound congener profiles court-proof?

Uhlig, Steffen; Eichler, Stefanie (2011)

Published in:

Journal of Chromatography A 1218 (33), p. 5688–5693.

http://dx.doi.org/10.1016/j.chroma.2011.06.080

Can the usual validation standard series for quantitative methods, ISO 5725, be also applied for qualitative methods?

Uhlig, Steffen; Niewöhner, Ludwig; Gowik, Petra (2011)

Published in:

Accreditation and Quality Assurance 16 (11), p. 533–537.

http://dx.doi.org/10.1007/s00769-011-0811-0

Evaluation and validation of a novel Arxula adeninivorans estrogen screen (nAES) assay and its application in analysis of wastewater, seawater, brackish water and urine. Special Section: Integrating Water and Agricultural Management Under Climate Change.

Kaiser, Christian; Uhlig, Steffen; Gerlach, Torsten; Körner, Martina; Simon, Kirsten; Kunath, Kirstin et al. (2010)

Published in:

Science of The Total Environment 408 (23), p. 6017–6026.

http://dx.doi.org/10.1016/j.scitotenv.2010.08.050

Factorial interlaboratory tests for microbiological measurement methods.

Uhlig, Steffen; Gowik, Petra (2010)

Published in:

Journal für Verbraucherschutz und Lebensmittelsicherheit 5 (1), p. 35–46.

http://dx.doi.org/10.1007/s00003-009-0524-z

Xplor® 2-an optimized transformation/expression system for recombinant protein production in the yeast Arxula adeninivorans.

Böer, Erik; Piontek, Michael; Kunze, Gotthard (2009)

Published in:

Appl Microbiol Biotechnol 84 (3), p. 583–594.

http://dx.doi.org/10.1007/s00253-009-2167-5

Ring Test Data Evaluation

Donnevert, Gerhild; Uhlig, Steffen; Moser, T. (2009)

Published in:

Jörg Römbke und Heidrun Moser (Hg.): Ecotoxicological Characterization of Waste. Results and Experiences of an International Ring Test. New York, NY: Springer-Verlag New York, p. 47–60.

http://dx.doi.org/10.1007/978-0-387-88959-7_4

Faktorielle Ringversuche zur Validierung mikrobiologischer Methoden

Uhlig, Steffen; Gowik, Petra (2009)

Published in:

Journal of Consumer Protection and Food Safety 5 (1)

Leitfaden zur Bewertung der Gleichwertigkeit von unterschiedlichen Messverfahren für anorganische und organische Schadstoffparameter im Rahmen der Bundes-Bodenschutz- und Altlastenverordnung (BBodSchV)

Uhlig, Steffen (2008)

Published in:

Hg. v. Umweltbundesamt. Fachbereich für Bodenuntersuchungen. Dessau-Roßlau.

https://www.umweltbundesamt.de/sites/default/files/medien/publikation/long/3510.pdf

Mit biologischem Testsystem gegen die Wasserverschmutzung. Hefezellenassay zur Erfassung von Östrogenen und östrogen wirksamen Substanzen

Simon, Kirsten; Uhlig, Steffen; Kunze, Gotthard; Körner, Martina (2008)

Published in.

GIT Laborfachzeitschrift (4), p. 374–375.

http://quodata.de/fileadmin/unternehmen/Pressemeldungen/assay_0408.pdf

Ringversuche als Bestandteil eines selbstevaluierenden Qualitätsmanagement-Systems.

Simon, Kirsten; Uhlig, Steffen (2008)

Published in:

In: LABO (7), p. 19–21.

http://www.labo.de/analyseninstrumente/instrumentelle-analytik---sofware-prolab.htm

GSR2005-Continuity of the ENFSI Proficiency Test on Identification of GSR by SEM/EDX

Niewöhner, Ludwig; Andrasko, Jan; Biegstraaten, Jan; Gunaratnam, Lawrence; Steffen, Sylvia; Uhlig, Steffen; Antoni, Sabine (2008)

Published in:

Journal of Forensic Sciences 53 (1), p. 162–167.

http://dx.doi.org/10.1111/j.1556-4029.2008.00594.x

Hormon-Detektion in flüssigen Matrices.

Simon, Kirsten; Uhlig, Steffen (2008)

Published in:

aqua press INTERNATIONAL (2), p. 34–35.

Methodische Grundlagen

Schaefer, Benedikt; Schindler, Peter; Uhlig, Steffen; Szewzyk, Regine (2008)

Published in:

Irmgard Feuerpfeil und Konrad Botzenhart (Hg.): Hygienisch-mikrobiologische Wasseruntersuchung in der Praxis. Nachweismethoden, Bewertungskriterien, Qualitätssicherung, Normen. Weinheim: Wiley-VCH, p. 5–37.

http://dx.doi.org/10.1002/9783527621941.ch2

Reference material in residue control: assessment of matrix effects

Gowik, Petra; Polzer, Joachim; Uhlig, Steffen (2007)

Published in:

Accreditation and Quality Assurance 12 (3), p. 161–166; http://dx.doi.org/10.1007/s00769-006-0220-y

Der Chromocult-Enterokokken-Agar als gleichwertiges Verfahren zum Nachweis und der Zählung von intestinalen Enterokokken nach DIN EN ISO 7899-2

Lange, Bernd; Uhlig, Steffen; Oßmer, Rolf; Melchert, Ines; Borchers, Ulrich (2007)

Published in:

Gas- und Wasserfach (GWF): Wasser, Abwasser 12 148 (12), p. 880–884.

Dioxins and dioxin-like PCBs in different fish from the river Elbe and its tributaries, Germany

Stachel, Burkhard; Christoph, Eugen H.; Götz, Rainer; Herrmann, Thomas; Krüger, Frank; Kühn, Thomas et al. (2007)

Published in:

Journal of Hazardous Materials 148 (1-2), p. 199–209; http://dx.doi.org/10.1016/j.jhazmat.2007.02.026

Dioxins and dioxin-like PCBs in different fish from the river Elbe and its tributaries, Germany

Stachel, Burkhard; Christoph, Eugen H.; Götz, Rainer; Herrmann, Thomas; Krüger, Frank; Kühn, Thomas et al. (2007)

Published in:

In: Journal of Hazardous Materials 148 (1-2), p. 199–209.

http://dx.doi.org/10.1016/j.jhazmat.2007.02.026

Reference material in residue control: assessment of matrix effects

Gowik, Petra; Polzer, Joachim; Uhlig, Steffen (2007)

Published in:

Accreditation and Quality Assurance 12 (3), p. 161–166.

http://dx.doi.org/10.1007/s00769-006-0220-y

Der Chromocult-Enterokokken-Agar als gleichwertiges Verfahren zum Nachweis und der Zählung von intestinalen Enterokokken nach DIN EN ISO 7899-2

Lange, Bernd; Uhlig, Steffen; Oßmer, Rolf; Melchert, Ines; Borchers, Ulrich (2007)

Published in:

In: Gas- und Wasserfach (GWF): Wasser, Abwasser 12 148 (12), p. 880–884.

Contamination of the alluvial plain, feeding-stuffs and foodstuffs with polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans (PCDD/Fs), dioxin-like polychlorinated biphenyls (DL-PCBs) and mercury from the River Elbe in the light of the flood event in August 2002

Stachel, Burkhard; Christoph, Eugen H.; Götz, Rainer; Herrmann, Thomas; Krüger, Frank; Kühn, Thomas et al. (2006)

Published in:

Science of The Total Environment 364 (1-3), p. 96–112; http://dx.doi.org/10.1016/j.scitotenv.2005.07.004

Statistical evaluation with dioxin patterns in different fish species from the river Elbe, Germany

Stachel, Burkhard; Kühn, Thomas; Reincke, Heinrich; Schröter-Kermani, Christa; Uhlig, Steffen (2006)

Published in:

Fresenius environmental bulletin 15 (12B), p. 1624–1631.

Macrozoobenthos interlaboratory comparison on taxonomical identification and counting of marine invertebrates in artificial sediment samples including testing various statistical methods of data evaluation

Schilling, Petra; Powilleit, Martin; Uhlig, Steffen (2006)

Published in:

Accreditation and Quality Assurance 11 (8), p. 422–429; http://dx.doi.org/10.1007/s00769-006-0139-3

Chlorophyll-a determination: Results of an interlaboratory comparison

Schilling, Petra; Powilleit, Martin; Uhlig, Steffen (2006)

Published in:

Accreditation and Quality Assurance 11 (8), p. 462–469; http://dx.doi.org/10.1007/s00769-006-0158-0

Regionalisierung von Grundwassergüteparametern

Scheidleder, Andreas; Grath, Johannes; Schramm, Claudia; Uhlig, Steffen (2006)

Published in:

Dieter Gutknecht (Hg.): Methoden der hydrologischen Regionalisierung. ÖWAV-Seminar im Lebensministerium, 18. - 19. Mai. Österreichischer Wasser- und Abfallwirtschaftsverband; ÖWAV-Seminar. Wien: Inst. für Wasserbau und Ingenieurhydrologie Technische Universität Wien (Wiener Mitteilungen, 197), p. 207–222.

A novel estrogen sensor based on recombinant Arxula adeninivorans cells

Hahn, Thomas; Tag, Kristina; Riedel, Klaus; Uhlig, Steffen; Baronian, Keith; Gellissen, Gerd; Kunze, Gotthard (2006)

Published in:

Biosensors and Bioelectronics 21 (11), p. 2078–2085; http://dx.doi.org/10.1016/j.bios.2005.10.019

Maintenance of the ENFSI Proficiency Test Program on Identification of GSR by SEM/EDX (GSR2003)

Niewöhner, Ludwig; Andrasko, Jan; Biegstraaten, Jan; Gunaratnam, Lawrence; Steffen, Sylvia; Uhlig, Steffen (2005)

Published in:  

Journal of Forensic Sciences 50 (4), p. 1–6; http://dx.doi.org/10.1520/JFS2004454

Automatisierte Messung von Hormonen im Wasser

Uhlig, Steffen; Simon, Kirsten; Bäuml, Georg; Graß, Benedikt; Schick, Norbert (2005)

Published in:

In: Laborwelt 6 (2), p. 3–4; http://www.laborwelt.de/fileadmin/dateien/PDF-Ausgaben/2005/LW2005_02.pdf

The Elbe flood in August 2002 - occurrence of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans (PCDD/F) and dioxin-like PCB in suspended particulate matter (SPM), sediment and fish

Stachel, Burkhard; Götz, Rainer; Herrmann, Thomas; Krüger, Frank; Knoth, Wilhelm; Päpke, Olaf et al. (2004)

Published in:

Water Science and Technology 50 (5), p. 309–316.

Vergleichsanalyse zur Bestimmung von polychlorierten Dibenzo-p-dioxinen und polychlorierten Dibenzofuranen (PCDD/F) in zwei Feststoffproben

Stachel, Burkhard; Schick, Norbert (2004)

Published in:

Walter Geller, Klaus Ockenfeld, Michael Böhme und Arndt Knöchel (Hg.): Schadstoffbelastung nach dem Elbe-Hochwasser 2002. Schadstoffuntersuchungen nach dem Hochwasser vom August 2002 - Ermittlung der Gefährdungspotentiale an Elbe und Mulde. Endbericht des Ad-hoc-Projekts, p. 27–29.

Stellungnahme zur Veröffentlichung der AG pharmakologisch wirksamer Stoffe der GDCh in Zeitschrift "Lebensmittelchemie" zum Thema Methodenvalidierung mit dem Titel "Validierung von Verfahren zur Untersuchung auf pharmakologisch wirksame Stoffe im Routinelabor"

Uhlig, Steffen; Gowik, Petra (2004)

Published in:

Lebensmittelchemie 58, p. 56–57.

Performance of a matrix-comprehensive in-house validation study by means of an especially designed software

Uhlig, Steffen; Gowik, Petra; Radeck, Wolfgang (2003)

Published in:

Analytika Chimica Acta 483 (1-2), p. 351–362; http://dx.doi.org/10.1016/S0003-2670(02)01025-5

Statistical evaluation and QS measures for on site analytics

Uhlig, Steffen; Simon, Kirsten (2002)

Published in

Wolfgang Breh, Johannes Gottlieb, Heinz Hötzl, Frieder Kern, Tanja Lisch und Reinhard Niesser (Hg.): Field screening Europe 2001. Proceedings of the Second International Conference on Strategies and Techniques for the Investigation and Monitoring of Contaminated Sites. Dordrecht: Kluwer Academic Publishers, p. 353–356

Langzeittrends des Phytoplanktons in der Ostsee

Wasmund, Norbert; Uhlig, Steffen (2002)

Published in:

Bund/Länder-Messprogramm Nord- und Ostsee (BLMP) AG Qualitätssicherung (Hg.): Meeresmonitoring und Qualitätssicherung. Zusammenstellung der Beiträge. Erfahrungsaustausch. Internationale Naturschutzakademie Insel Vilm, 5.-6. November. Umweltbundesamt. Berlin, p. 75–82; https://www.umweltbundesamt.de/sites/default/files/medien/publikation/long/3107.pdf

Statistische Aspekte bei der Auswertung von Grundwasserqualitätsdaten nach den Vorgaben der EU-Wasserrahmenrichtlinie (WRRL)

Grath, Johannes; Uhlig, Steffen; Scheidleder, Andreas; Weber, K. (2001)

Published in:

Österreichische Wasser- und Abfallwirtschaft 53 (5-6), p. 128–138; http://cat.inist.fr/?aModele=afficheN&cpsidt=1136096

Estimation of variance components with high breakdown point and high efficiency

Müller, Christine H.; Uhlig, Steffen (2001)

Published in:

Biometrika 88 (2), p. 353–366; http://dx.doi.org/10.1093/biomet/88.2.353

In-house-Validierung in der Spurenanalytik

Gowik, Petra; Uhlig, Steffen (1999)

Published in:

Nachrichten aus Chemie, Technik und Laboratorium 47 (1), p. 49; http://dx.doi.org/10.1002/nadc.19990470123 

A top-down in-house validation based approach for the investigation of the measurement uncertainty using fractional factorial experiments

Jülicher, Bernd; Gowik, Petra; Uhlig, Steffen (1999)

Published in:

The Analyst 124 (4), p. 537–545; http://dx.doi.org/10.1039/A807077F

Statistische Trendanalysen bei marinen Monitoringdaten - aktuelle Diskussionen

Uhlig, Steffen (1999)

Published in:

Deutsche hydrographische Zeitschrift 51 (10), p. 181–185; http://dx.doi.org/10.1007/BF02933706

In-house-Validierung in der Spurenanalytik

Gowik, Petra (1998)

Published in: 

Nachrichten aus Chemie, Technik und Laboratorium 46 (9), p. 841–844; http://dx.doi.org/10.1002/nadc.19980460910

Multi-residue method for non-steroidal anti-inflammatory drugs in plasma using high-performance liquid chromatography–photodiode-array detection

Gowik, Petra; Jülicher, Bernd; Uhlig, Steffen (1998)

Published in:

Journal of Chromatography B: Biomedical Sciences and Applications 716 (1-2), p. 221–232; http://dx.doi.org/10.1016/S0378-4347(98)00343-0

Assessment of detection methods in trace analysis by means of a statistically based in-house validation concept

Jülicher, Bernd; Gowik, Petra; Uhlig, Steffen (1998)

Published in:

The Analyst 123 (2), p. 173–179; http://dx.doi.org/10.1039/A707281C

Statistically-based performance characteristics in laboratory performance studies

Uhlig, Steffen; Lischer, Peter (1998)

Published in:

The Analyst 123 (2), p. 167–172; http://dx.doi.org/10.1039/A705432G

Zur Kombination von Tabellen- und Regressionsmethode bei dem Berliner Mietspiegel 1992

Schlittgen, Rainer; Uhlig, Steffen (1997)

Published in:

Allgemeines Statistisches Archiv 81 (4), p. 401–405.

Limits of tolerance and z-scores in ring tests

Uhlig, Steffen; Henschel, Peter (1997)

Published in:

Fresenius Journal of Analytical Chemistry 358 (7-8), p. 761–766; http://dx.doi.org/10.1007/s002160050505

Robuste Schätzung in Kovarianzmodellen mit Anwendungen im Qualitätsmanagement und in Finanzmärkten. Freie Universität Berlin

Uhlig, Steffen (1997)

Available upon request.

Robust Estimation of Variance Components with High Breakdown Point in the 1-Way Random Effect Model

Uhlig, Steffen (1997)

Published in:

Christos P. Kitsos und Lutz Edler (Hg.): Industrial Statistics. Aims and Computational Aspects. Proceedings. Satellite Conference to the 51st session of the International Statistical Institute (ISI). Athens, Greece, 16. - 17. August. International Statistical Institute. Heidelberg: Physica-Verl. (Contributions to statistics), p. 65–73.

Joint analysis of mean and variance function based on second order polynomials

Uhlig, Steffen (1997)

Published in:

Hans-Joachim Lenz (Hg.): Frontiers in Statistical Quality Control 5. Vth International Workshop on Intelligent Statistical Quality Control. University of Osaka Prefecture, Osaka, Japan, 1996. Physica-Verl.

Optimum two-way nested designs for estimation of variance components

Uhlig, Steffen (1996)

Published in:

Tatra Mountains Mathematical Publications (7), p. 105–112; http://tatra.mat.savba.sk/paper.php?id_paper=194#

Dublettenermittlung bei Zusammenführung von Bibliotheken: (Nicht nur) ein statistisches Verfahren

Kende, Jiri; Uhlig, Steffen (1995)

Published in:

Bibliothek Forschung und Praxis 19 (3), p. 411–419; https://opacplus.bsb-muenchen.de/search?id=gbv582617995&db=255

Bundesweite Ringversuche zur neuen Klärschlammverordnung. Teil 2

Harnisch, Manfred; Henschel, Peter; Uhlig, Steffen; Wilrich, Peter-Theodor (1994)

Published in:

LaborPraxis (1), p. 18–24.

Analysis of Dispersion Effects in Fractional Factorial Two-Level Designs

Uhlig, Steffen (1993)

Published in:

Alexander J. Karmann, Karl Clemens Mosler, Martin Schader und Götz Uebe (Hg.): Operations Research '92. Extended abstracts. 17th Symposium on Operations Research. Universität der Bundeswehr Hamburg, 25. - 28. August 1992. Gesellschaft für Mathematik, Ökonomie und Operations-Research. Heidelberg: Physica-Verl., p. 394–396.

Bestimmung von Nachweisgrenzen mittels Kalibrierexperimenten

Uhlig, Steffen (1993)

Published in:

ECOINFORMA 4 (285-296).